image of lab member Guo Luo

Guo Luo, PhD

Position

Research Scientist

Pronouns

he/him

About

I'm an immunologist with a special interest in T cell immunology. My projects involve isolating and characterizing T cell clones reactive to autoantigens and flu antigens using DNA barcoded tetramers/dextramers. Most of my work is applied to narcolepsy, an autoimmune disease associated with HLA-DQ0602, that is triggered by the flu and involves flu-orexin cross-reactive CD4 T cells. I hope to understand how T cell cross reactivity occurs in the context of neuroimmune disorders targeting neurons. We sort multimer positive cells, characterize TCRs functionally and apply single cell sequencing.

Latest Publications

2020
Treatment of narcolepsy with natalizumab

Thomas E Scammell and Guo Luo and Priya Borker and Lee Sullivan and Kelsey Biddle and Emmanuel Mignot

2020
Why Did Pandemrix Trigger Narcolepsy? A Structural Approach

V Peris Sempere and A Ambati and G Luo and L Lin and E Mignot

2020
Autoimmunity to Hypocretin/Orexin and Molecular Mimicry to Flu in Type 1 Narcolepsy (4989)

Guo Luo and Aditya Ambati and Ling Lin and Markku Partinen and Xuhuai Ji and Holden Maecker and Emmanuel Mignot

2020
Mass Spectrometric Characterization of Narcolepsy-Associated Pandemic 2009 Influenza Vaccines

Aditya Ambati and Guo Luo and Elora Pradhan and Jacob Louis and Ling Lin and Ryan D Leib and Hanna Maria Ollila and Thomas Poiret and Christopher Adams and Emmanuel Mignot

2019
0016 Autoimmunity To Hypocretin And Molecular Mimicry To Flu In Type 1 Narcolepsy

Guo Luo and Aditya Ambati and Ling Lin and Mélodie Bonvalet and Markku Partinen and Xuhuai Ji and Holden Terry Maecker and Emmanuel Jean-Marie Mignot

2019
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases (vol 12, e0187305, 2017)

Guo Luo and Ling Lin and Louis Jacob and Melodie Bonvalet and Aditya Ambati and Giuseppe Plazzi and Fabio Pizza and Ryan Leib and Christopher M Adams and Markku Partinen and Emmanuel Jean-Marie Mignot

2019
Correction: Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases

Guo Luo and Ling Lin and Louis Jacob and Mélodie Bonvalet and Aditya Ambati and Giuseppe Plazzi and Fabio Pizza and Ryan Leib and Christopher M Adams and Markku Partinen and Emmanuel Jean-Marie Mignot and PLOS ONE Editors

2018
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Guo Luo and Aditya Ambati and Ling Lin and Mélodie Bonvalet and Markku Partinen and Xuhuai Ji and Holden Terry Maecker and Emmanuel Jean-Marie Mignot

2018
Autoimmunity to hypocretin and molecular mimicry to flu antigens in Type 1 narcolepsy

Guo Luo and Aditya Ambati and Ling Lin and Mélodie Bonvalet and Markku Partinen and Xuhuai Ji and Holden Terry Maecker and Emmanuel Jean-Marie Mignot