image of lab member Guo Luo

Guo Luo, PhD

Position

Clinical Instructor

About

I'm an immunologist with a special interest in T cell immunology. My projects involve isolating and characterizing T cell clones reactive to autoantigens and flu antigens using DNA barcoded tetramers/dextramers. Most of my work is applied to narcolepsy, an autoimmune disease associated with HLA-DQ0602, that is triggered by the flu and involves flu-orexin cross-reactive CD4 T cells. I hope to understand how T cell cross reactivity occurs in the context of neuroimmune disorders targeting neurons. We sort multimer positive cells, characterize TCRs functionally and apply single cell sequencing.

Latest Publications

2023
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Hanna M Ollila and Eilon Sharon and Ling Lin and Nasa Sinnott-Armstrong and Aditya Ambati and Selina M Yogeshwar and Ryan P Hillary and Otto Jolanki and Juliette Faraco and Mali Einen and Guo Luo and Jing Zhang and Fang Han and Han Yan and Xiao Song Dong and Jing Li and Jun Zhang and Seung-Chul Hong and Tae Won Kim and Yves Dauvilliers and Lucie Barateau and Gert Jan Lammers and Rolf Fronczek and Geert Mayer and Joan Santamaria and Isabelle Arnulf and Stine Knudsen-Heier and May Kristin Lyamouri Bredahl and Per Medbøe Thorsby and Giuseppe Plazzi and Fabio Pizza and Monica Moresco and Catherine Crowe and Stephen K Van den Eeden and Michel Lecendreux and Patrice Bourgin and Takashi Kanbayashi and Francisco J Martínez-Orozco and Rosa Peraita-Adrados and Antonio Benetó and Jacques Montplaisir and Alex Desautels and Yu-Shu Huang and Poul Jennum and Sona Nevsimalova and David Kemlink and Alex Iranzo and Sebastiaan Overeem and Aleksandra Wierzbicka and Peter Geisler and Karel Sonka and Makoto Honda and Birgit Högl and Ambra Stefani and Fernando Morgadinho Coelho and Vilma Mantovani and Eva Feketeova and Mia Wadelius and Niclas Eriksson and Hans Smedje and Pär Hallberg and Per Egil Hesla and David Rye and Zerrin Pelin and Luigi Ferini-Strambi and Claudio L Bassetti and Johannes Mathis and Ramin Khatami and Adi Aran and Sheela Nampoothiri and Tomas Olsson and Ingrid Kockum and Markku Partinen and Markus Perola and Birgitte R Kornum and Sina Rueger and Juliane Winkelmann and Taku Miyagawa and Hiromi Toyoda and Seik-Soon Khor and Mihoko Shimada and Katsushi Tokunaga and Manuel Rivas and Jonathan K Pritchard and Neil Risch and Zoltan Kutalik and Ruth O’Hara and Joachim Hallmayer and Chun Jimmie Ye and Emmanuel J Mignot

2023
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen and Guo Luo and Aditya Ambati and Vincent Damotte and Iris Jansen and Eric Yu and Aude Nicolas and Itziar de Rojas and Thiago Peixoto Leal and Akinori Miyashita and Céline Bellenguez and Michelle Mulan Lian and Kayenat Parveen and Takashi Morizono and Hyeonseul Park and Benjamin Grenier-Boley and Tatsuhiko Naito and Fahri Küçükali and Seth D Talyansky and Selina Maria Yogeshwar and Vicente Sempere and Wataru Satake and Victoria Alvarez and Beatrice Arosio and Michael E Belloy and Luisa Benussi and Anne Boland and Barbara Borroni and María J Bullido and Paolo Caffarra and Jordi Clarimon and Antonio Daniele and Daniel Darling and Stéphanie Debette and Jean-François Deleuze and Martin Dichgans and Carole Dufouil and Emmanuel During and Emrah Düzel and Daniela Galimberti and Guillermo Garcia-Ribas and José María García-Alberca and Pablo García-González and Vilmantas Giedraitis and Oliver Goldhardt and Caroline Graff and Edna Grünblatt and Olivier Hanon and Lucrezia Hausner and Stefanie Heilmann-Heimbach and Henne Holstege and Jakub Hort and Yoo Jin Jung and Deckert Jürgen and Silke Kern and Teemu Kuulasmaa and Kun Ho Lee and Ling Lin and Carlo Masullo and Patrizia Mecocci and Shima Mehrabian and Alexandre de Mendonça and Mercè Boada and Pablo Mir and Susanne Moebus and Fermin Moreno and Benedetta Nacmias and Gael Nicolas and Shumpei Niida and Børge G Nordestgaard and Goran Papenberg and Janne Papma and Lucilla Parnetti and Florence Pasquier and Pau Pastor and Oliver Peters and Yolande AL Pijnenburg and Gerard Piñol-Ripoll and Julius Popp and Laura Molina Porcel and Raquel Puerta and Jordi Pérez-Tur and Innocenzo Rainero and Inez Ramakers and Luis M Real and Steffi Riedel-Heller and Eloy Rodriguez-Rodriguez and Owen A Ross and Jose Luís Royo and Dan Rujescu and Nikolaos Scarmeas and Philip Scheltens and Norbert Scherbaum and Anja Schneider and Davide Seripa and Ingmar Skoog and Vincenzo Solfrizzi and Gianfranco Spalletta and Alessio Squassina and John van Swieten and Raquel Sánchez-Valle and Eng-King Tan and Thomas Tegos and Charlotte Teunissen and Jesper Qvist Thomassen and Lucio Tremolizzo and Martin Vyhnalek and Frans Verhey and Margda Waern and Jens Wiltfang and Jing Zhang and EADB and GR@ ACE study group and DEGESCO consortium and DemGene and EADI and GERAD and Asian Parkinson’s Disease Genetics consortium and Henrik Zetterberg and Kaj Blennow and Zihuai He and Julie Williams and Philippe Amouyel and Frank Jessen and Patrick G Kehoe and Ole A Andreassen and Cornelia Van Duin and Magda Tsolaki and Pascual Sánchez-Juan and Ruth Frikke-Schmidt and Kristel Sleegers and Tatsushi Toda and Anna Zettergren and Martin Ingelsson and Yukinori Okada and Giacomina Rossi and Mikko Hiltunen and Jungsoo Gim and Kouichi Ozaki and Rebecca Sims and Jia Nee Foo and Wiesje van der Flier and Takeshi Ikeuchi and Alfredo Ramirez and Ignacio Mata and Agustín Ruiz and Ziv Gan-Or and Jean-Charles Lambert and Michael D Greicius and Emmanuel Mignot

2022
Protective association of HLA‐DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences

Yann Le Guen and Guo Luo and Aditya Ambati and Vincent Damotte and Iris E Jansen and Eric Yu and Aude Nicolas and Itziar de Rojas and Thiago Peixoto Leal and Akinori Miyashita and Céline Bellenguez and Michelle Mulan Lian and Kayenat Parveen and Takashi Morizono and Hyeonseul Park and Benjamin Grenier‐Boley and Tatsuhiko Naito and Fahri Küçükali and Seth D Talyansky and Selina Marie Yogeshwar and Vicente Sempere and Wataru Satake and Victoria Álvarez‐Martínez and Beatrice Arosio and Michael E Belloy and Luisa Benussi and Anne Boland and Barbara Borroni and María J Bullido and Paolo Caffarra and Jordi Clarimon and Antonio Daniele and Daniel Darling and Stéphanie Debette and Jean‐François Deleuze and Martin Dichgans and Carole Dufouil and Emmanuel During and Emrah Duzel and Daniela Galimberti and Guillermo García‐Ribas and Jose María García‐Alberca and Pablo García‐González and Vilmantas Giedraitis and Oliver Goldhardt and Caroline Graff and Edna Grunblatt and Olivier Hanon and Lucrezia Hausner and Stefanie Heilmann‐Heimbach and Henne Holstege and Jakub Hort and Yoo Jin Jung and Deckert Jurgen and Silke Kern and Teemu Kuulasmaa and Kun Ho Lee and Ling Ling and Carlo Masullo and Patrizia Mecocci and Shima Mehrabian and Alexandre de Mendonça and Mercè Boada and Pablo Mir and Susanne Moebus and Fermin Moreno and Benedetta Nacmias and Gaël Nicolas and Shumpei Niida and Børge G Nordestgaard and Goran Papenberg and Janne M Papma and Lucilla Parnetti and Florence Pasquier and Pau Pastor and Oliver Peters and Yolande AL Pijnenburg and Gerard Piñol‐Ripoll and Julius Popp and Laura Molina and Raquel Puerta and Jordi Pérez‐Tur and Innocenzo Rainero and Luis Miguel Real and Steffi G Riedel‐Heller and Eloy Rodríguez Rodríguez and José Luís Royo and Dan Rujescu and Nikolaos Scarmeas and Philip Scheltens and Norbert Scherbaum and Anja Schneider and Davide Seripa and Ingmar Skoog and Vincenzo Solfrizzi and Gianfranco Spalletta and Alessio Squassina and John C van Swieten and Raquel Sanchez‐Valle and Eng‐King Tan and Thomas Tegos and Charlotte E Teunissen and Jesper Qvist Thomassen and Lucio Tremolizzo and Martin Vyhnalek and Frans RJ Verhey and Margda Waern and Jens Wiltfang and Jing Zhang and Henrik Zetterberg and Kaj Blennow and Julie Williams and Philippe Amouyel and Frank Jessen and Patrick G Kehoe and Ole Andreassen and Cornelia M Van Duijn and Magda Tsolaki and Pascual Sanchez‐Juan and Ruth Frikke‐Schmidt and Kristel Sleegers and Tatsushi Toda and Anna Zettergren and Martin Ingelsson and Yukinori Okada and Giacomina Rossi and Mikko Hiltunen and Jungsoo Gim and Kouichi Ozaki and Rebecca Sims and Jia Nee Foo and Wiesje M van der Flier and Takeshi Ikeuchi and Alfredo Ramirez and Ignacio Mata and Agustin Ruiz and Ziv Gan‐Or and Jean‐Charles Lambert and Michael D Greicius and Emmanuel Mignot

2021
T cell reactivity to regulatory factor X4 in type 1 narcolepsy

Guo Luo and Selina Yogeshwar and Ling Lin and Emmanuel Jean-Marie Mignot

2020
Treatment of narcolepsy with natalizumab

Thomas E Scammell and Guo Luo and Priya Borker and Lee Sullivan and Kelsey Biddle and Emmanuel Mignot

2020
Mass spectrometric characterization of Narcolepsy-Associated pandemic 2009 influenza vaccines

Aditya Ambati and Guo Luo and Elora Pradhan and Jacob Louis and Ling Lin and Ryan D Leib and Hanna Maria Ollila and Thomas Poiret and Christopher Adams and Emmanuel Mignot

2019
Correction: Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases

Guo Luo and Ling Lin and Louis Jacob and Mélodie Bonvalet and Aditya Ambati and Giuseppe Plazzi and Fabio Pizza and Ryan Leib and Christopher M Adams and Markku Partinen and Emmanuel Jean-Marie Mignot and PLOS ONE Editors

2019
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases (vol 12, e0187305, 2017)

Guo Luo and Ling Lin and Louis Jacob and Melodie Bonvalet and Aditya Ambati and Giuseppe Plazzi and Fabio Pizza and Ryan Leib and Christopher M Adams and Markku Partinen and Emmanuel Jean-Marie Mignot