image of lab member Emmanuel Mignot

Emmanuel Mignot, MD.PhD

Position

Craig Reynolds Professor of Sleep Medicine

Pronouns

he/him

About

Dr. Mignot is Craig Reynolds Professor of Sleep Medicine at Stanford University.  He discovered that human narcolepsy is caused by the autoimmune loss of ~20,000 hypothalamic neurons secreting the wake-promoting peptide hypocretin/orexin.  He identified HLA-DQB1*06:02 and T-Cell receptor genes as major susceptibility genes across ethnic groups, which act together to promote a highly selective T cell mediated autoimmune process triggered by influenza infection. Dr. Mignot has received numerous awards and is a member of the National Academies of Sciences and Medicine. He works on many aspects of sleep research and on unravelling the etiologies of various  autoimmune diseases affecting the brain. His approaches are strongly analytic, and include genetics, proteomics, statistics and deep learning.

Latest Publications

2021
MSED: a multi-modal sleep event detection model for clinical sleep analysis

Alexander Neergaard Olesen and Poul Jennum and Emmanuel Mignot and Helge BD Sorensen

2020
Sodium Oxybate Treatment Effects on Sleep Architecture in Pediatric Patients With Narcolepsy With Cataplexy (1172)

Emmanuel Mignot and Richard K Bogan and Jed Black and Rupa Parvataneni and Diane Menno and Y Grace Wang and Yves Dauvilliers

2020
Deep transfer learning for improving single-EEG arousal detection

Alexander Neergaard Olesen and Poul Jennum and Emmanuel Mignot and Helge Bjarup Dissing Sorensen

2020
Cataplexy-Free Days With Sodium Oxybate Treatment in Children/Adolescents With Narcolepsy With Cataplexy (1211)

Emmanuel Mignot and Carol L Rosen and Diane Menno and Y Grace Wang and Judi Profant and Yves Dauvilliers

2020
Treatment of narcolepsy with natalizumab

Thomas E Scammell and Guo Luo and Priya Borker and Lee Sullivan and Kelsey Biddle and Emmanuel Mignot

2020
Acoustic stimulation time-locked to the beginning of sleep apnea events reduces oxygen desaturations: a pilot-study

Adrien Waeber and Pierrick J Arnal and Gianpaolo Lecciso and David Albir and Emmanuel Mignot and Raphael Heinzer

2020
The Association Between REM Sleep and Risk of Mortality in Three Independent Cohorts

EB Leary and KT Watson and S Ancoli-Israel and S Redline and K Yaffe and LA Ravelo and PE Peppard and J Zou and S Goodman and E Mignot and KL Stone

2020
Why Did Pandemrix Trigger Narcolepsy? A Structural Approach

V Peris Sempere and A Ambati and G Luo and L Lin and E Mignot

2020
Effects of Sodium Oxybate (SXB) on Body Mass Index (BMI) in Pediatric Patients With Narcolepsy

Y Dauvilliers and GJ Lammers and M Lecendreux and G Plazzi and K Maski and S Kansagra and E Mignot and D Menno and Y Wang and CL Rosen