image of lab member Emmanuel Mignot

Emmanuel Mignot, MD,PhD


Craig Reynolds Professor of Sleep Medicine


Dr. Mignot is Craig Reynolds Professor of Sleep Medicine at Stanford University. He discovered that human narcolepsy is caused by the autoimmune loss of ~70,000 hypothalamic neurons secreting the wake-promoting peptide hypocretin/orexin. He identified HLA-DQB1*06:02 and T-Cell receptor genes as major susceptibility genes across ethnic groups, which act together to promote a highly selective T cell mediated autoimmune process triggered by influenza infection. Dr. Mignot has received numerous awards including the 2023 Breakthrough Prize. He is a member of the National Academies of Sciences and Medicine. He works on many aspects of sleep research and on unravelling the etiologies of various autoimmune diseases affecting the brain. His approaches are strongly analytic, and include genetics, proteomics, statistics, and deep learning.

Latest Publications

Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium

Parichita Choudhury and Joyce K Lee-Iannotti and Andrea O Busicescu and Pooja Rangan and Maria Livia Fantini and Alon Y Avidan and Donald L Bliwise and Susan R Criswell and Emmanuel H During and Jonathan E Elliott and Julie A Fields and Jean-Francois Gagnon and Michael J Howell and Daniel E Huddleston and Jennifer McLeland and Emmanuel Mignot and Mitchell G Miglis and Miranda M Lim and Amélie Pelletier and Carlos H Schenck and David Shprecher and Erik K St Louis and Aleksandar Videnovic and Yo-El S Ju and Bradley F Boeve and Ronald Postuma and NAPS Consortium

Role of Daytime Continuous Polysomnography in the Diagnosis of Pediatric Narcolepsy Type 1

Fabio Pizza and Luca Vignatelli and Stefano Vandi and Corrado Zenesini and Francesco Biscarini and Christian Franceschini and Elena Antelmi and Francesca Ingravallo and Emmanuel Mignot and Oliviero Bruni and Lino Nobili and Pierangelo Veggiotti and Raffaele Ferri and Giuseppe Plazzi

Prevalence and Course of Idiopathic Hypersomnia in the Wisconsin Sleep Cohort Study

David T Plante and Erika W Hagen and Jodi H Barnet and Emmanuel Mignot and Paul E Peppard

Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment

Kasey N Davis and Ping-Ping Qu and Shining Ma and Ling Lin and Melanie Plastini and Niklas Dahl and Giuseppe Plazzi and Fabio Pizza and Ruth O’Hara and Wing Hung Wong and Joachim Hallmayer and Emmanuel Mignot and Xianglong Zhang and Alexander E Urban

The sleep and wake electroencephalogram over the lifespan

Haoqi Sun and Elissa Ye and Luis Paixao and Wolfgang Ganglberger and Catherine J Chu and Can Zhang and Jonathan Rosand and Emmanuel Mignot and Sydney S Cash and David Gozal and Robert J Thomas and M Brandon Westover

Excessive daytime sleepiness in primary care–Authors' reply

Laura Pérez-Carbonell and Emmanuel Mignot and Guy Leschziner and Yves Dauvilliers

Genetics of circadian rhythms and sleep in human health and disease

Jacqueline M Lane and Jingyi Qian and Emmanuel Mignot and Susan Redline and Frank AJL Scheer and Richa Saxena

Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls

Eva Wiberg Torstensen and Niels Christian Haubjerg Østerby and Fabio Pizza and Giuseppe Plazzi and Elena Antelmi and Monica Moresco and Emmanuel Mignot and Niklas Rye Jørgensen and Gitte Lund Christensen and Benedikte Wanscher and Birgitte Rahbek Kornum and Poul Jørgen Jennum

Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990–2017

Xiling Wang and Fulong Xiao and Yiping Wang and Xiaowei Deng and Zhiyuan Chen and Xiaosong Dong and Wei Wang and Chenyang Li and Zhifei Xu and Huijuan Wu and Huan Yu and Changjun Su and Zan Wang and Xiangdong Tang and Yunhui Lv and Yun Li and Shuchen Sun and Junying Huang and Lijuan Hao and Xuan Wei and Liying Deng and Yu-Shu Huang and Jihui Zhang and Yun-Kwok Wing and Jun Zhang and Emmanuel Mignot and Fang Han and Hongjie Yu

The genetic etiology of periodic limb movement in sleep

Jacob L Edelson and Logan D Schneider and David Amar and Andreas Brink-Kjaer and Katie L Cederberg and Zoltán Kutalik and Erika W Hagen and Paul E Peppard and Priscila Farias Tempaku and Sergio Tufik and Daniel S Evans and Katie Stone and Greg Tranah and Brian Cade and Susan Redline and Jose Haba-Rubio and Raphael Heinzer and Pedro Marques-Vidal and Peter Vollenweider and Juliane Winkelmann and James Zou and Emmanuel Mignot